Molecular Dialogue between Parasite and Hosts: the Trypanosome Model Inter-University Attraction Pole

pai        partners        objectives        people        publications        reports        agenda        links A project supported by the "Belgian Science Policy" (BSP) Contract No: PAI-IUAP N. P6/15 Start date: January 1, 2007 End date: December 31, 2011 To study the molecular mechanisms used by parasites to undergo developmental transformations and to adapt to their hosts by using the African trypanosomes (prototype Trypanosoma brucei) as model organisms. This project can be divided into two parts: Studies on the parasite Endocytosis of host macromolecules (TCD, ULB) Cell signalling (LMUM, ULB) Controls of gene expression (ULB) Metabolic changes during the parasite life-cycle Study of host-parasite interactions Mechanisms underlying pathology in mammalian hosts (VUB) Macrophage – trypanosome interactions (VUB, ULB) Tsetse fly – trypanosome interactions (ITG, ULB, VUB) Bloodstream form trypanosomes of Trypanosoma brucei surrounded by red blood cells (courtesy Jürgen Berger)   Expert evaluation area (password required)

6 Dec 2007 Suggestions, questions ... ==> Etienne Pays