Postdoctoral position

Role of ClC-5 in endocytosis : in vitro studies, ICP/UCL, Brussels (Pierre Courtoy and Olivier Devuyst)

The Cell Biology Unit at ICP (P. Courtoy) has a long expertise in the study of endocytosis in vivo and in cellular models. Together with O. Devuyst (UCL, Nephrology Unit), we are dissecting the molecular alterations underlying various genetic models of kidney proximal tubular defects, referred to as Fanconi syndromes. One of these, Dent's disease, is caused by inactivating mutations of the chloride channel, ClC-5, and is reproduced in KO mice. In vivo studies have shown that ClC-5 inactivation severely inhibits endocytic uptake of ultrafiltrated proteins (e.g. PNAS 100:8472-8477, 2003) and trafficking of the sodium phosphate co-transporter, NaPi II (Nature 408:369-373, 2000). We are establishing a cellular model of ClC-5 inactivation to clarify its role in membrane trafficking.
A postdoctoral position within EuReGene consortium (http://iscience.de/euregene/) is available as of Feb 1, 2005. The ICP is a multidisciplinary institute with state-of-the-art research infrastructure, located close to the attractive city of Brussels (http://www.icp.ucl.ac.be).

The candidate should hold a Ph.D. or equivalent and have a broad expertise in molecular biology and interest in cell biology.
Interested individuals should apply by submitting their curriculum vitae, including a brief description of their research interests and skills and the names and addresses of three references.

Contact address :

Prof. P. Courtoy, CELL, ICP/UCL, 75 av. Hippocrate, B-1200 Brussels, Belgium. Phone : +32-2-764.75.69; fax : +32-2-764.75.43; e-mail : courtoy@cell.ucl.ac.be.

For other doctoral and post-doctoral fellowships, see also :
	Training and Fellowships at the ICP